🌀 BioFlo TFF / Ultrafiltration Planner

Model tangential flow filtration (TFF) and cassette sizing: Transmembrane Pressure ($TMP = \frac{P_{feed} + P_{ret}}{2} - P_{perm}$), Permeate Flux ($J = \text{LMH}$), Volumetric Concentration Factor ($VCF$), and Diafiltration Volume ($DV$) buffer exchange.

Operating Pressures & Membrane Area
Feed Batch & Diafiltration Target
5 DV exchanges ~ 99.3% of original buffer.
Calculated Hydrodynamics & Processing Schedule
20.0 psi
Transmembrane Pressure (TMP)
10.0 psi
Feed Channel Drop (ΔP)
10.0×
Concentration Factor (VCF)
22.5 L/h
Permeate Flow Rate (Qp)
2.0 h
Concentration Step Time
1.1 h
Diafiltration Time
3.1 h
Total TFF Run Duration
25.0 L
Diafiltration Buffer Needed