The sustainable production of complex, high-value chemicals requires integrating precise biological pathway manipulation (metabolic engineering) with robust chemical process design (bioprocess engineering) to bridge the gap between laboratory potential and industrial scale.
The downstream purification (DSP) phase is the critical bottleneck in viral vector manufacturing. This article details multi-modal strategies, including affinity, ion exchange, and continuous chromatography, required to achieve high purity and yield at industrial scale.
The nervous system relies on neurons, specialized cells, to transmit electrical and chemical signals. Understanding the core components—soma, dendrites, and axon—and the role of myelination is key to comprehending biological communication.
This article details the application of Model Predictive Control (MPC) to manage complex aquatic systems. MPC utilizes real-time measurements of key parameters like pH, Dissolved Oxygen (DO), and glucose to predict future system states and…
This article details a robust, multi-stage separation train that combines Ultrafiltration (UF) and selective Adsorption chromatography to achieve high-purity bioproduct recovery from complex fermentation broths, overcoming limitations of traditional single-stage methods.
Traditional media formulations are static and fail to account for dynamic metabolic shifts. Metabolomics provides a global, unbiased snapshot of the cellular metabolic state, enabling the identification of rate-limiting factors and allowing for targeted, data-driven…
This article explores the complex biochemical mechanisms by which microorganisms degrade various pollutants, detailing the critical roles of electron acceptors and the transition from reductive to oxidative metabolic pathways.
This article explores the critical role of advanced computational modeling, integrating fluid dynamics (CFD) and metabolic kinetics, to optimize large-scale bioreactor performance. By predicting spatial variations and metabolic shifts, engineers can enhance cell viability and…
This article explores the critical role of Computational Fluid Dynamics (CFD) in simulating bioreactor performance. It details how RANS models are used to predict complex flow patterns and how species transport equations model the concentration…
Scaling up bioprocesses in high-viscosity media presents significant challenges related to mass transfer limitations, heat removal, and mixing heterogeneity. This article details the mechanistic basis of scale-up failure and outlines advanced strategies, including specialized impeller…