Predictive Bioreactor CAD & Multiphase CFD Simulation Engineered for Scale
Full-physics Eulerian-Eulerian multiphase CFD, sliding mesh turbulence modeling (k-ε / SST k-ω), and ASME BPE parametric 3D CAD design. We solve hydrodynamic shear stress dissipation, gas holdup (εg), and dynamic kLa oxygen mass transfer kinetics to eliminate scale-up risk from 1L benchtop to 25,000L+ industrial fermenters.
Parametric vessels, Rushton & hydrofoil impellers, DFM STEP models
Eulerian gas-liquid, bubble breakup (PBM), sliding mesh & MRF
Constant P/V, tip speed limits, & oxygen mass transfer kinetics
Our Core Services
High-accuracy CFD simulation, yield optimization, scale-up modeling, and digital twin validation for bioreactors, storage tanks, and fluid systems.
CFD Simulation
Detailed fluid flow, velocity streamlines, mixing patterns, turbulence, and dead-zone elimination for tanks, pipes, and vessels.
CFD Simulation Details βProcess Optimization
Maximize fermentation titer yield, shorten batch cycle times, and optimize gas-liquid mass transfer (kLa) and feed distribution.
Optimization Services βScale Up Engineering
De-risk scale-up transitions from 1L benchtop to 10,000L+ industrial production without yield drops or shear damage.
Scale-Up Engineering βValidation & Digital Twins
In-silico testing, structural integrity verification, and physics-based validation reports for tech-transfer and compliance.
Validation Reports βSelected Bioreactor & CFD Projects
Predictive engineering and multi-phase fluid dynamics deployed to maximize fermentation titers and resolve hydrodynamic bottlenecks.
10,000L Scale-Up
Industrial Fermenter Scale-Up
Eulerian-Eulerian two-fluid modeling and bubble population balance dynamics in a 10mΒ³ stirred-tank bioreactor.
Mass Transfer
kLa Oxygen Transfer Modeling
Dynamic gas-liquid mass transfer rate modeling and dissolved oxygen prediction across aerobic bacterial cultures.
Hydrodynamics
Impeller Shear & Power Analysis
Sliding mesh analysis optimizing Rushton turbines vs. hydrofoil impellers for shear-sensitive biological products.
BioFlo Bioprocess Engineering Workbench
Engineered by bioprocess engineers for fermentation suites and pilot plants. Free, interactive computational engines to eliminate manual math, de-risk scale-up, and accelerate bioprocess operations.
BioFlo Bioprocess Engineering Workbench
The all-in-one digital bioprocess engineering workbench for pilot plants, scale-up modeling, and fermentation suites. 14 validated bioprocess engines in one unified workbench.
kLa Predictor
Forecast oxygen mass transfer coefficients across gassed stirred tanks using Van’t Riet and Linek correlations.
Launch in Workbench βMixing Time
Calculate 95% blend uniformity time (ΞΈββ ), power draw, and tip speed across Rushton and pitched impellers.
Launch in Workbench βBioreactor Scale-Up
Evaluate scale-up criteria: constant P/V, tip speed, mixing time, and Reynolds regime across vessel scales (1L to 25,000L).
Launch in Workbench βSterilization & Lethality (Fβ)
Calculate thermal death kinetics, Del factor (β), Fβ lethality values, and autoclave sterilization cycles.
Launch in Workbench βConsolidated Bioprocess Engineering Workbench
Includes Bioreactor Scale-Up, kLa Mass Transfer, OTR/OUR Balance, Monod Kinetics, Fβ Autoclave Cycles, TFF Filtration, and Column Sizing.
In-Depth Bioprocess Guides & Scale-Up Insights
Peer-grade bioprocess engineering guides, mass-transfer derivations, and computational fluid dynamics methodologies developed for biomanufacturing scale-up.
Scale-Up
Bioreactor Scale-Up Framework: From 1L to 25,000L
Analyzing constant tip speed, power per unit volume (P/V), and kLa criteria while mitigating mixing dead zones and shear stress.
Mass Transfer
Predicting & Optimizing kLa in Fermentations
Derivation of Van ‘t Riet correlations, dynamic gassing-out sensor lag, and multi-impeller aeration regimes.
Laboratory AI
PetriPlate AI: Automated Colony Counting
Eliminating human counting variability with circular Hough transforms, watershed segmentation, and dilution planners.
CFD & Shear
CFD Modeling: Multiphase Hydrodynamics & Shear
Eulerian-Eulerian multiphase formulation, Kolmogorov microscale shear thresholds, and impeller gas-cavity regimes.
BioFlo Mobile Apps β Native Bioprocess & Infrastructure Tools
We’re bringing automated AI laboratory imaging and bio-compute server administration straight to Android smartphones.
BioFlo PetriCount (Android)
Mobile AI Agar Colony Counter
Snap an agar Petri plate with your phone’s camera. The on-device neural network segments, classifies, and counts microbial colonies, applying serial dilution multipliers in under 2 seconds.
cPanel Manager (Android)
Native Mobile Web Hosting Admin
Direct mobile control panel for cPanel hosting. Monitor real-time CPU, RAM, and Disk metrics, explore file directories, inspect databases, and automate ACME SSL deployment.
50+
Projects Completed
98%
Client Satisfaction
5
Years Experience
10+
Experts
Unlock the performance of your bioreactor
From mixing and oxygen transfer to scale-up and process optimization, we use computational modeling and engineering analysis to identify bottlenecks and improve reactor performance.