Predictive Bioreactor Design & CFD Simulation Engineered for Scale
Data-driven computational fluid dynamics (CFD), multiphase hydrodynamics, and bioprocess simulation to eliminate scale-up risk and maximize yield.
Our Core Services
High-accuracy CFD simulation, yield optimization, scale-up modeling, and digital twin validation for bioreactors, storage tanks, and fluid systems.
CFD Simulation
Detailed fluid flow, velocity streamlines, mixing patterns, turbulence, and dead-zone elimination for tanks, pipes, and vessels.
CFD Simulation Details →Process Optimization
Maximize fermentation titer yield, shorten batch cycle times, and optimize gas-liquid mass transfer (kLa) and feed distribution.
Optimization Services →Scale Up Engineering
De-risk scale-up transitions from 1L benchtop to 10,000L+ industrial production without yield drops or shear damage.
Scale-Up Engineering →Validation & Digital Twins
In-silico testing, structural integrity verification, and physics-based validation reports for tech-transfer and compliance.
Validation Reports →Selected Bioreactor & CFD Projects
Predictive engineering and multi-phase fluid dynamics deployed to maximize fermentation titers and resolve hydrodynamic bottlenecks.
10,000L Scale-Up
Industrial Fermenter Scale-Up
Eulerian-Eulerian two-fluid modeling and bubble population balance dynamics in a 10m³ stirred-tank bioreactor.
Mass Transfer
kLa Oxygen Transfer Modeling
Dynamic gas-liquid mass transfer rate modeling and dissolved oxygen prediction across aerobic bacterial cultures.
Hydrodynamics
Impeller Shear & Power Analysis
Sliding mesh analysis optimizing Rushton turbines vs. hydrofoil impellers for shear-sensitive biological products.
20+ Production-Grade Web Applications
Engineered by bioprocess scientists for bioprocess scientists. Free, interactive computational engines to eliminate manual math, de-risk scale-up, and accelerate lab workflows.
kLa Predictor
Forecast oxygen mass transfer coefficients across gassed stirred tanks using Van’t Riet and Linek correlations.
Launch kLa App →Mixing Time
Calculate 95% blend uniformity time (θ₉₅), power draw, and tip speed across Rushton and pitched impellers.
Launch Mixing App →BioCalc Suite
Molarity, buffer recipes (Tris, PBS, HEPES), serial dilution calculators, and media formulations.
Launch BioCalc →PetriPlate AI & CFU
Computer vision microbial colony counter and dilution protocol planner for accurate CFU/mL calculations.
Launch CFU Planner →Explore All 21 Applications
Includes DOI2Cite, CiteSmart, CytoCount, PCR MasterMix Assist, Bioreactor Geometry Builder, and more.
In-Depth Bioprocess Guides & Scale-Up Insights
Peer-grade bioprocess engineering guides, mass-transfer derivations, and computational fluid dynamics methodologies developed for biomanufacturing scale-up.
Scale-Up
Bioreactor Scale-Up Framework: From 1L to 25,000L
Analyzing constant tip speed, power per unit volume (P/V), and kLa criteria while mitigating mixing dead zones and shear stress.
Mass Transfer
Predicting & Optimizing kLa in Fermentations
Derivation of Van ‘t Riet correlations, dynamic gassing-out sensor lag, and multi-impeller aeration regimes.
Laboratory AI
PetriPlate AI: Automated Colony Counting
Eliminating human counting variability with circular Hough transforms, watershed segmentation, and dilution planners.
CFD & Shear
CFD Modeling: Multiphase Hydrodynamics & Shear
Eulerian-Eulerian multiphase formulation, Kolmogorov microscale shear thresholds, and impeller gas-cavity regimes.
Upcoming Android Mobile Applications
We’re bringing automated AI laboratory imaging and bio-compute server administration straight to Android smartphones.
BioFlo PetriCount (Android)
Mobile AI Colony Counter
Snap an agar Petri plate with your phone’s camera. The on-device neural network segments, classifies, and counts microbial colonies, applying serial dilution multipliers in under 2 seconds.
cPanel Manager (Android)
Bio-Compute Cloud Admin
Real-time server infrastructure management tailored for bio-computational clusters. Monitor server CPU, memory, active web calculation microservices, databases, and SSL certificates on the go.
50+
Projects Completed
98%
Client Satisfaction
5
Years Experience
10+
Experts
Unlock the performance of your bioreactor
From mixing and oxygen transfer to scale-up and process optimization, we use computational modeling and engineering analysis to identify bottlenecks and improve reactor performance.