Bridging Microbial Kinetics, Fluid Dynamics & Industrial Scale-Up
BioFlo delivers computational fluid dynamics (CFD) simulation, precision bioreactor design, and digital twin models to de-risk biomanufacturing from benchtop to 10,000L+ commercial scale.
Why Conventional Scale-Up Fails
Bioreactors operate at the delicate intersection of fluid hydrodynamics, gas-liquid mass transfer, and living cellular biology. Traditional scale-up relies on rules of thumb (like constant volumetric power P/V or tip speed) in isolation—leading to unexpected oxygen starvation, shear damage, and dead-zone foaming at commercial scales.
The BioFlo Solution: We solve coupled transport phenomena where residence time (τ), dilution rate (D), oxygen mass transfer (kLa), and microbial kinetics (μ) are resolved simultaneously inside validated 3D multiphase CFD environments.
What BioFlo Delivers
High-fidelity engineering capabilities designed for biopharma, fermentation, and biotech manufacturers.
CFD Simulation
3D single-phase and multiphase fluid dynamics modeling. Quantify velocity contours, dead zones, impeller power numbers, and shear stress distributions.
Process Optimization
Yield maximization, cycle time reduction, and oxygen transfer (kLa) tuning. Eliminate nutrient starvation and thermal gradients in high-density cultures.
Scale Up Engineering
De-risking technology transfer from 1L benchtop to 10,000L+ industrial vessels. Maintain consistent shear environments and matched mixing times.
Validation & Digital Twins
Design qualification (DQ/IQ/OQ) compliance dossiers, in-silico stress tests, and real-time kinetic digital twin integration for regulatory compliance.
Our Engineering Rigor & Computational Standards
✓ Mesh Independence & GCI
Every simulation undergoes strict Grid Convergence Index (GCI) verification to eliminate numerical discretization errors.
✓ Eulerian-Eulerian Multiphase
Population balance bubble tracking for precise sparging, holdup, and interfacial mass transfer predictions.
✓ Strict IP & Mutual NDA
We sign bilateral mutual NDAs prior to any CAD geometry or fermentation operational data exchange.
✓ 24-Hour Feasibility Review
Rapid engineering scoping and transparent simulation milestone deliverables within 24 hours.
Ready to Optimize or Scale Your Bioreactor?
Consult directly with our simulation engineers. Share your reactor geometry or operational challenges for a confidential feasibility assessment.