The global biomanufacturing sector is shifting toward circular bioeconomies by developing integrated bioprocess platforms. These systems simultaneously valorize waste streams (resource recovery) and synthesize high-value biochemicals (product synthesis), overcoming the limitations of traditional sequential methods.
Traditional anaerobic digestion (AD) faces limitations due to kinetic bottlenecks and unstable conditions. Electro-bioreactors (EBRs) offer an advanced solution by applying an external electrical potential, which fundamentally enhances microbial activity, stabilizes the process, and accelerates…
As microbial fermentation scales, limitations like substrate depletion and product inhibition necessitate a shift from traditional batch to continuous culture systems. This transition enables steady-state operation, maximizing efficiency for high-value bioproducts.
Cascade bioproduction is a critical synthetic biology approach that integrates multiple enzymatic pathways into a single microbial host to sustainably synthesize complex high-value chemicals, overcoming the limitations of traditional petrochemical synthesis.
Pervaporation is an advanced separation technique that addresses the energy and selectivity challenges inherent in purifying dilute bioproducts. By utilizing a selective membrane barrier, it facilitates separation based on differential permeation, bypassing traditional energy-intensive phase…
This article explores advanced formulation strategies, particularly focusing on managing viscosity in high-solids systems. Techniques ranging from polymer selection to particle size modification are discussed to ensure product stability and usability.
This article details the shift from traditional batch fermentation to advanced continuous culture systems, such as chemostats and perfusion reactors. It explores the critical operational considerations for high-density microbial fermentation, including managing mass transfer limitations,…
This article details the critical mechanisms of cryoprotection, focusing on the role of cryoprotectants (CPAs) in preventing cellular damage during freezing. It further outlines the essential operational considerations for successfully scaling up cryopreserved microbial strains…
This article compares the chemical properties, uses, and safety considerations of sodium hydroxide (NaOH) and sodium hypochlorite (NaOCl), two common industrial chemicals.
This article details how Machine Learning derived predictive models are integrated into Model Predictive Control (MPC) algorithms to optimize bioprocess operations. MPC solves complex optimization problems at each time step to determine the optimal sequence…