Computational Fluid Dynamics (CFD)

In-Silico Characterization of Bioprocess Environments

The BioFlo CFD Suite

We bridge the gap between pure hydrodynamics and microbial growth. Our modeling workflow quantifies the heterogeneity of the bioreactor environment, ensuring that lab-scale performance translates to industrial success.

Multiphase Flow Modeling

Utilizing VOF (Volume of Fluid) and Euler-Euler approaches to track gas-liquid interfaces and bubble trajectories in complex flow fields.

Turbulence & Shear Analysis

Mapping the local dissipation rate (\(\epsilon\)) to identify regions of potential cell damage using high-fidelity \(k-\epsilon\) and \(k-\omega\) SST models.

Biological Coupling

A CFD model is only as good as its biological relevance. We solve the scalar transport equations for dissolved oxygen \(DO\) by coupling hydrodynamics with the biological Oxygen Uptake Rate \(OUR\):

\frac{\partial (C_{DO})}{\partial t} + \nabla \cdot (\mathbf{u} C_{DO}) = \nabla \cdot (D_{eff} \nabla C_{DO}) + k_L a (C^* – C_{DO}) – OUR

Where \(OUR\) is defined by Monod kinetics, allowing us to visualize nutrient gradients and hypoxic zones in real-time simulation.

Simulation Capabilities

Solver Integration: Native support for interFoam, buoyantPimpleFoam, and custom BioFlo C++ solvers.
Meshing: Automated hex-dominant meshing for complex impellers and sparger geometries.
Post-Processing: Velocity streamline mapping, dead-zone volume quantification, and mixing time (\(\theta_{95}\)) calculation.

Ready to Validate Your Design?

Get detailed hydrodynamic reports for your bioreactor configurations.

Contact for Modeling Services