Electro-bioreactors (EBRs) offer an advanced solution to overcome the kinetic and stability limitations of traditional anaerobic digestion (AD). By applying an external electrical potential, EBRs enhance electron transfer kinetics, accelerating the degradation of complex waste streams and improving methane yield.
This article details the critical components and operational considerations for successful cell cryopreservation, focusing on cryoprotectant agents (CPAs) and the technical challenges of scaling up cell culture processes in bioreactors.
Bioprocessing requires advanced control strategies to manage complex, time-varying biological systems. Model Predictive Control (MPC) and Adaptive Control (AC) are essential for transitioning from reactive PID control to proactive, predictive management, ensuring optimal yield and stability.
Protein crystallization offers a highly efficient, cost-effective, and scalable alternative to traditional chromatography for purifying proteins. This process requires sophisticated engineering control over supersaturation, nucleation, and crystal growth to transition from a lab technique to an industrial scale.
This article explores advanced bioreactor strategies for overcoming thermodynamic equilibrium limitations, focusing on the critical role of continuous product removal flux to drive reactions past natural equilibrium points.
The biopharmaceutical industry is transitioning from traditional batch processing to continuous flow systems to enhance efficiency, reduce variability, and improve resource utilization in therapeutic protein manufacturing.
This article details the critical biological processes of nitrification and denitrification, and explores advanced membrane bioreactor (MBR) systems for enhanced wastewater treatment. It further discusses resource recovery strategies, specifically struvite precipitation, to convert waste streams into valuable fertilizers.
In situ product removal (ISPR) is a critical technology that continuously separates and removes target biomolecules from the bioreactor stream during bioprocessing. This approach mitigates product inhibition, enhances yield, and transforms biomanufacturing into a continuous, intensified process.
Self-assembling nanostructures offer a paradigm shift in bioproduction by providing a highly controllable, stimuli-responsive, and spatially defined platform for localized, high-efficiency bioproduction directly at the site of disease.
This article details the advanced techniques used in cryopreservation, including controlled cooling rates and vitrification, and outlines the critical steps for safely reviving cryostored cells by removing cryoprotectants.