Advanced Process Control (APC), particularly Model Predictive Control (MPC), is essential for managing the complex, non-linear dynamics of fed-batch biomanufacturing. It moves control from reactive setpoint following to proactive, predictive optimization, enabling higher yields and…
The global shift away from fossil fuels necessitates advanced biofuel production utilizing non-food lignocellulosic biomass. Metabolic engineering redesigns *Saccharomyces cerevisiae* to efficiently co-utilize mixed sugars and convert them into high-value biofuels, overcoming limitations associated with…
Traditional process control systems struggle with the non-linear, time-varying dynamics of advanced bioprocesses. This article details how integrating Machine Learning, particularly LSTM networks within a Model Predictive Control (MPC) framework, enables predictive, real-time optimization of…
This article details the enzymatic synthesis of aldehydes, utilizing a coupled glucose oxidation pathway to regenerate $ ext{NADPH}$. We discuss the operational considerations, including enzyme stability, immobilization techniques, and process optimization for industrial scale-up.
Continuous flow reactors (CFRs) are revolutionizing industrial biotechnology by offering superior control and productivity compared to traditional batch systems. By maintaining steady-state conditions, CFRs overcome limitations like product inhibition and substrate depletion, enabling high-density, scalable…
The global transition toward a circular bioeconomy necessitates sustainable alternatives to fossil fuels. Integrated biorefineries maximize value extraction from lignocellulosic biomass by co-producing multiple high-value bioproducts from a single feedstock stream.
Smart sensor arrays are revolutionizing bioprocessing by enabling continuous, real-time monitoring of Critical Quality Attributes (CQAs) directly within the bioreactor. By integrating electrochemical and optical sensing modalities onto a single microfluidic chip, these arrays overcome…
Metabolomics provides a comprehensive, snapshot view of the entire cellular metabolome, transforming media optimization from an empirical art into a data-driven science by identifying metabolic bottlenecks and optimizing nutrient inputs.
Self-assembling nanostructures offer a paradigm shift in drug delivery by providing highly tunable, nanoscale carriers. By leveraging fundamental physical and chemical principles, these systems spontaneously form complex architectures *in situ* or *ex vivo*, enabling highly…
Tangential Flow Filtration (TFF) is a critical biopharmaceutical unit operation for concentrating, diafiltering, and purifying biological macromolecules. Optimizing TFF parameters is essential to maximize throughput while ensuring robust viral clearance and product safety.