Maintaining precise thermal profiles across interconnected bioreactor trains is critical for industrial biotechnology. This requires managing heat transfer at micro, meso, and macro scales to ensure optimal microbial growth, product quality, and operational efficiency.

This paper explores using Computational Fluid Dynamics (CFD) to optimize flow dynamics in Airlift Bioreactors (ALBRs) by minimizing hydrodynamic shear stresses, thereby protecting shear-sensitive cell lines and improving bioprocess robustness.

Downstream Processing: From Broth to Fuel The fermentation broth contains a mixture of product, biomass, and residual substrates. Efficient separation is essential for commercial viability: Downstream processing can contribute significantly to overall energy consumption; hence… 

Reducing Variability in Microbial Analysis Using BioFlo Tools Introduction Microbial analysis workflows in many laboratories continue to rely on manual colony counting and spreadsheet-based calculations. While these approaches are widely accepted, they introduce significant variability,… 

Fermentation Optimization Maximizing Titers, Yields, and Productivity through Kinetic Modeling The Science of Yield Optimization at BioFlo goes beyond simple parameter tuning. We analyze the metabolic bottleneck of your strain by coupling stoichiometry with dynamic… 

kLa in Bioreactors: From Oxygen Transfer to Process Optimization kLa in Bioreactors: From Oxygen Transfer to Process Optimization In aerobic bioprocessing, oxygen availability is often the primary rate-limiting factor. The volumetric mass transfer coefficient (kLa)…