Bioprocess Engineering – Page 2 – BioFlo

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CFD Modeling & Multiphase

Eulerian gas-liquid holdup, bubble sizing & shear

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Bioreactor Scale-Up (1L–25,000L+)

Hydrodynamic scaling, kLa matching & P/V limits

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De Novo Reactor Engineering

Custom impellers, spargers & baffle geometry

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3D Digital Twin Simulation

Real-time kinetic ODE coupling & interactive CAD
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🧪 Bioprocess Workbench Suite
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Bioreactor & Upstream
Bioreactor Scale-Up (1L–25kL) 5L Bioreactor CAD Twin Mixing Time (θ95) 3D Bioreactor Simulator

Mass Transfer & Gas Holdup
kLa Mass Transfer Predictor OTR / OUR Oxygen Balance CFD Multiphase Modeling De Novo Reactor Engineering

Fermentation Kinetics
Fermentation Kinetics (Monod) OD vs Time Growth Regression OD600 Cell Density Converter Fed-Batch Feeding Planner

Downstream & Sterilization
Thermal Sterilization (F₀) TFF / Ultrafiltration Planner Chromatography Column Sizer BatchCompare Golden Envelope

15 validated bioprocess calculators & simulators Launch All 15 Industrial Tools →
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🌀 CFD Modeling & Multiphase 🚀 Bioreactor Scale-Up (1L–25,000L+) ⚙️ De Novo Reactor Engineering 🖥️ 3D Digital Twin Simulation

Work 3 Case Studies →

• Bioreactor Scale-Up (1L–25,000L) • 5L Bioreactor 3D CAD Twin • kLa Mass Transfer Predictor • Mixing & Blend Time (θ95) • OTR / OUR Oxygen Balance • Fermentation Kinetics (Monod) • OD vs Time Growth Kinetics • Fed-Batch Trajectory Planner • Thermal Sterilization (F₀) • TFF Ultrafiltration Planner • 3D Bioreactor ODE Simulator Launch All 15 Industrial Tools →

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Automated Laboratory Microbiological Fermentor and Feeding Skid

Fed-Batch Fermentation Feeding Strategies: Derivations, Overflow Metabolism, and Closed-Loop PAT Control

09/21/202610/25/2026
Upstream & Fermentation (category)

Derive fed-batch exponential feeding rates, suppress acetate overflow, and implement closed-loop DO-stat/pH-stat PAT control for high-density fermentations.

Industrial Continuous Stirred Tank Reactor (CSTR AISI 316)

Gas Hold-Up and Power Draw in Aerated Stirred-Tank Bioreactors: Mechanics, Michel-Miller Correlations, and Impeller Cavities

09/21/202610/25/2026
Upstream & Fermentation (category)

Hydrodynamic guide to gas hold-up and gassed power draw in aerated bioreactors. Michel-Miller correlations, impeller cavity regimes, and motor sizing formulas.

The Comprehensive Bioreactor Scale-Up Framework: From 1L Benchtop to 25,000L Production

09/07/202610/25/2026
CFD & Bioreactor Scale-Up (category)

Complete bioprocess scale-up guide: comparing constant tip speed, P/V, and kLa criteria. Includes modular bioreactor skid architecture and P&ID manifolds.