What role does membrane cell retention play in continuous bioprocessing?

External cross-flow ultrafiltration membranes recycle microbial biomass back to the CSTR, decoupling hydraulic retention time (HRT) from solid retention time (SRT) and multiplying volumetric productivity.

Mixing Time – BioFlo

End-to-end continuous lignocellulosic biorefinery flowsheet with CSTR membrane retention CFD and AI monitoring

Continuous Biorefinery Intensification: From Lignocellulosic Saccharification and Syngas Microsparging to CFD-Optimized Membrane CSTRs

10/06/202610/25/2026
Upstream & Fermentation (category)

Continuous biorefinery process intensification: lignocellulosic biomass pretreatment, syngas microbubble mass transfer, CFD hydrodynamics, and membrane CSTRs.

Bioreactor hydrostatic pressure volume gradient bubble expansion and dissolved gas solubility schematic

The Pressure-Volume Scaling Paradox in Stirred-Tank Bioreactors: Decoupling Power-to-Volume (P/V), Hydrostatic Gradients, and Headspace Overpressure

10/05/202610/25/2026
CFD & Bioreactor Scale-Up (category), Upstream & Fermentation (category)

Resolve the pressure-volume scaling paradox in stirred bioreactors: liquid head hydrostatic gradients (ρgh), bubble expansion, pCO2 accumulation, and P/V.

Laboratory Bioreactor for Shear-Sensitive Cell Culture

Hydrodynamic Shear Stress in Bioreactors: Kolmogorov Microscales, Bubble Bursting, and Mammalian Cell Fragility

09/21/202610/25/2026
CFD & Bioreactor Scale-Up (category)

Hydrodynamic shear stress in stirred bioreactors: Kolmogorov eddy microscales, bubble-burst energy dissipation, and shear damage thresholds for CHO cells.

Continuous Biorefinery Intensification: From Lignocellulosic Saccharification and Syngas Microsparging to CFD-Optimized Membrane CSTRs

The Pressure-Volume Scaling Paradox in Stirred-Tank Bioreactors: Decoupling Power-to-Volume (P/V), Hydrostatic Gradients, and Headspace Overpressure

Hydrodynamic Shear Stress in Bioreactors: Kolmogorov Microscales, Bubble Bursting, and Mammalian Cell Fragility

BioFlo

Bioprocess Workbench

Engineering & Modeling

Contact & Inquiries

BioFlo

Bioprocess Workbench

Engineering & Modeling

Contact & Inquiries