Master bioreactor process optimization: DO cascade control, pH trimming, fed-batch feeding formulas, and DoE design spaces for CHO & microbial cultures.
A masterclass in bioprocess cGMP compliance: 21 CFR Part 11 data integrity, scale-dependent CQA drift, EU GMP Annex 1 sterility, and continuous PAT validation.
Why spectrophotometric OD600 misleads downstream engineering: how dead cell debris collapses TFF flux by 70%, and how Edge-AI colony counting restores yield.
Intensify biotherapeutic purification with multi-column continuous chromatography (PCC & SMB). Master breakthrough equations, resin yield, and mAb math.
Continuous biorefinery process intensification: lignocellulosic biomass pretreatment, syngas microbubble mass transfer, CFD hydrodynamics, and membrane CSTRs.
Derive fed-batch exponential feeding rates, suppress acetate overflow, and implement closed-loop DO-stat/pH-stat PAT control for high-density fermentations.
